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Article

Flies without centrioles.

Cell - 30 Jun 2006

Basto Renata, Lau Joyce, Vinogradova Tatiana, Gardiol Alejandra, Woods C Geoffrey, Khodjakov Alexey, Raff Jordan W

Abstract excerpt

Centrioles and centrosomes have an important role in animal cell organization, but it is uncertain to what extent they are essential for animal development. The Drosophila protein DSas-4 is related to the human microcephaly protein CenpJ and the C. elegans centriolar protein Sas-4. We show that DSas-4 is essential for centriole replication in flies. DSas-4 mutants start to lose centrioles during embryonic...

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Identifiers

PMID: 16814722
DOI: 10.1016/j.cell.2006.05.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Flies without centrioles.PMID 16814722Read ↗

DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly.Semantic proximity Read ↗

SAS-4 is a C. elegans centriolar protein that controls centrosome size.Semantic proximity Read ↗

<i>C. elegans</i> SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1Semantic proximity Read ↗

The Chromatin Remodeling Protein CHD-1 and the EFL-1/DPL-1 Transcription Factor Cooperatively Down Regulate CDK-2 to Control SAS-6 Levels and Centriole NumberSemantic proximity Read ↗

The <i>C. elegans</i> homolog of Sjögren’s Syndrome Nuclear Antigen 1 is required for the structural integrity of the centriole and bipolar mitotic spindle assemblySemantic proximity Read ↗

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo.Semantic proximity Read ↗

Alström Syndrome protein Alms1 is required for maintaining meiotic centriole engagement in spermatocytes of <i>Drosophila</i>Semantic proximity Read ↗

Centrosome loss in the evolution of planarians.Semantic proximity Read ↗

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A homeostatic clock sets daughter centriole size in flies.Semantic proximity Read ↗

CCDC15 localizes to the centriole inner scaffold and regulates centriole integrity and ciliogenesisSemantic proximity Read ↗

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