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Article

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers.

Science (New York, N.Y.) - 12 Mar 1999

do Carmo Avides M, Glover D M

Abstract excerpt

The product of the abnormal spindle (asp) gene was found to be an asymmetrically localized component of the centrosome during mitosis, required to focus the poles of the mitotic spindle in vivo. Removing Asp protein function from Drosophila melanogaster embryo extracts, either by mutation or immu...

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Source

Identifiers

PMID: 10073938
DOI: 10.1126/science.283.5408.1733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10073938-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers.PMID 10073938Read ↗

The drosophila protein asp is involved in microtubule organization during spindle formation and cytokinesis.Semantic proximity Read ↗

The abnormal spindle protein is required for germ cell mitosis and oocyte differentiation during Drosophila oogenesis.Semantic proximity Read ↗

An Asp-CaM complex is required for centrosome-pole cohesion and centrosome inheritance in neural stem cells.Semantic proximity Read ↗

A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila.Semantic proximity Read ↗

The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.Semantic proximity Read ↗

Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization.Semantic proximity Read ↗

Human ASPM participates in spindle organisation, spindle orientation and cytokinesis.Semantic proximity Read ↗

Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle.Semantic proximity Read ↗

mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila.Semantic proximity Read ↗

Mutations at the asp locus of Drosophila lead to multiple free centrosomes in syncytial embryos, but restrict centrosome duplication in larval neuroblasts.Semantic proximity Read ↗

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and developmentSemantic proximity Read ↗

Interactions between mgr, asp, and polo: asp function modulated by polo and needed to maintain the poles of monopolar and bipolar spindles.Semantic proximity Read ↗

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