Article
Wild-type and met-65-->Leu variants of human cystatin A are functionally and structurally identical.
Biochemistry - 26 Dec 2000
Craven C J, Baxter N J, Murray E H, Hill N J, Martin J R, Ylinenjärvi K, Björk I, Waltho J P, Murray I A
Abstract excerpt
The solution structure of an N-terminally truncated and mutant form (M65L(2-98)) of the human cysteine protease inhibitor cystatin A has been reported that reveals extensive structural differences when compared to the previously published structure of full-length wild-type (WT) cystatin A. On the basis of the M65L(2-98) structure, a model of the inhibitory mechanism of cystatin A was proposed wherein specific...
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