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Article

High-resolution structure of bovine pancreatic trypsin inhibitor with altered binding loop sequence.

Journal of molecular biology - 4 Feb 2000

Czapinska H, Otlewski J, Krzywda S, Sheldrick G M, Jaskólski M

Abstract excerpt

A mutant of bovine pancreatic trypsin inhibitor (BPTI) has been constructed and expressed in Escherichia coli in order to probe the kinetic and structural consequences of truncating the binding loop residues to alanine. In addition to two such mutations (Thr11Ala and Pro13Ala), it has a conservative Lys15Arg substitution at position P(1) and an unrelated Met52Leu change. In spite of the binding loop modification,...

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PMID: 10653700
DOI: 10.1006/jmbi.1999.3445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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