Article
Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases.
The Journal of biological chemistry - 16 Sept 1994
Balbín M, Hall A, Grubb A, Mason R W, López-Otín C, Abrahamson M
Abstract excerpt
Human cystatin D is a novel member of the cystatin superfamily of cysteine proteinase inhibitors present in saliva and tears. Two alleles of the cystatin D gene (CST5), encoding protein variants with either Cys or Arg as residue 26 in their 122-residue polypeptide chains, are present in the popul...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cystatins
- Cysteine Proteinase Inhibitors
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Genetic Variation
- Humans
- Immunochemistry
- Immunoelectrophoresis
- Molecular Sequence Data
- Saliva
- Structure-Activity Relationship