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Article

Crystallization and preliminary X-ray diffraction analysis of Val57 mutants of the amyloidogenic protein human cystatin C.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Dec 2011

Orlikowska Marta, Jankowska Elzbieta, Borek Dominika, Otwinowski Zbyszek, Skowron Piotr, Szymańska Aneta

Abstract excerpt

Human cystatin C (hCC) is a low-molecular-mass protein (120 amino-acid residues, 13 343 Da) found in all nucleated cells. Its main physiological role is regulation of the activity of cysteine proteases. Biologically active hCC is a monomeric protein, but all crystallization efforts have resulted in a dimeric domain-swapped structure. Recently, two monomeric structures were reported for cystatin C variants. In one...

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Identifiers

PMID: 22139178
DOI: 10.1107/S1744309111039741
PMCID: PMC3232151

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Source receipt: pubmed, retrieved 7 Sept 2026.

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