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Article

Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.

The Journal of biological chemistry - 5 Dec 2014

Skala Wolfgang, Utzschneider Daniel T, Magdolen Viktor, Debela Mekdes, Guo Shihui, Craik Charles S, Brandstetter Hans, Goettig Peter

Abstract excerpt

Human kallikrein-related peptidase 2 (KLK2) is a tryptic serine protease predominantly expressed in prostatic tissue and secreted into prostatic fluid, a major component of seminal fluid. Most likely it activates and complements chymotryptic KLK3 (prostate-specific antigen) in cleaving seminal clotting proteins, resulting in sperm liquefaction. KLK2 belongs to the "classical" KLKs 1-3, which share an extended 99-...

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Source

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Identifiers

PMID: 25326387
DOI: 10.1074/jbc.M114.598201
PMCID: PMC4256358

Genes

KLK2
KLK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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