Article
Absence of CD43 fails to alter T cell development and responsiveness.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2001
Carlow D A, Corbel S Y, Ziltener H J
Abstract excerpt
Genetic elimination of CD43 has been associated with increased T cell adhesiveness and T cell hyperresponsiveness to mitogens and alloantigens. Therefore, we investigated whether T cell development was perturbed in CD43-deficient mice by breeding CD43(null) mice with male Ag (Hy)-specific TCR-transgenic mice. Neither positive nor negative thymic selection of male Ag-specific T cells were affected by CD43 status....
Topics
- Animals
- Antigens, CD
- Cell Differentiation
- Cells, Cultured
- Crosses, Genetic
- Female
- H-Y Antigen
- Leukosialin
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Phenotype
- Receptors, Antigen, T-Cell
- Sex Factors