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Article

Leukocyte common antigen (CD45) is required for immunoglobulin E-mediated degranulation of mast cells.

The Journal of experimental medicine - 1 Aug 1994

Berger S A, Mak T W, Paige C J

Abstract excerpt

We demonstrate using primary mast cell cultures derived from wild-type and CD45-deficient mice that mast cell triggering through the high-affinity immunoglobulin E (IgE) receptor requires the cell surface tyrosine phosphatase CD45. Unlike wild-type cells, cross-linking of surface-bound IgE in mast cells deficient in CD45 does not induce degranulation. Degranulation in these mutant cells does occur after treatment...

Topics

Anaphylaxis
Animals
B-Lymphocytes
Calcimycin
Cell Degranulation
Cell Line
Flow Cytometry
Immunoglobulin E
Leukocyte Common Antigens
Mast Cells
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Receptors, Antigen, T-Cell

Vanadates

Source

Open in PubMed Open full text

Identifiers

PMID: 8046327
DOI: 10.1084/jem.180.2.471
PMCID: PMC2191589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8046327-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Leukocyte common antigen (CD45) is required for immunoglobulin E-mediated degranulation of mast cells.PMID 8046327Read ↗

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