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Article

Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997

Gottshall K R, Hunter J J, Tanaka N, Dalton N, Becker K D, Ross J, Chien K R

Abstract excerpt

To overcome the genetic and interindividual variability frequently noted in complex phenotypes, we used echocardiographic selection to develop a substrain of myosin light chain (MLC)-Ras (RAS) transgenic mice with an enhanced ventricular hypertrophic phenotype. These echo-selected mice were then...

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Gene Expression
Genetic Variation
Mice
Mice, Inbred C57BL
Mice, Transgenic
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Fusion Proteins

Selection, Genetic

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Identifiers

PMID: 9114056
DOI: 10.1073/pnas.94.9.4710
PMCID: PMC20789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9114056-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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