Article
Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997
Gottshall K R, Hunter J J, Tanaka N, Dalton N, Becker K D, Ross J, Chien K R
Abstract excerpt
To overcome the genetic and interindividual variability frequently noted in complex phenotypes, we used echocardiographic selection to develop a substrain of myosin light chain (MLC)-Ras (RAS) transgenic mice with an enhanced ventricular hypertrophic phenotype. These echo-selected mice were then compared with wild-type (WT) animals and a pressure overload hypertrophy model (transverse aortic constriction; TAC)....
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