Article
Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype.
Clinical immunology (Orlando, Fla.) - 1 Nov 2003
Breen Elizabeth Crabb, Boscardin W John, Detels Roger, Jacobson Lisa P, Smith Michael W, O'Brien Stephen J, Chmiel Joan S, Rinaldo Charles R, Lai Shenghan, Martínez-Maza Otoniel
Abstract excerpt
Interleukin-10 (IL10) may contribute to the development of non-Hodgkin's B cell lymphoma, especially in the context of acquired immunodeficiency syndrome (AIDS), where lymphoma incidence is greatly increased. Utilizing specimens from the Multicenter AIDS Cohort Study (MACS) obtained prior to diagnosis of AIDS-associated lymphoma, detectable serum human IL10 was seen much more frequently in lymphoma cases (n = 61,...
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