Article
Decreased pulmonary vascular permeability in aquaporin-1-null humans.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002
King Landon S, Nielsen Søren, Agre Peter, Brown Robert H
Abstract excerpt
The molecular determinants of water permeability in the human lung are incompletely defined. Aquaporins (AQP) are water-specific membrane channel proteins. AQP1 is present in endothelial cells in the lung, including those in the vascular plexus around the airways. Rare individuals have been identified who are deficient in AQP1. High-resolution computed tomography scans of the lung were used to evaluate the...
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