Article
Complex genetics of Wegener granulomatosis.
Autoimmunity reviews - 1 Jan 2005
Jagiello Peter, Gross Wolfgang L, Epplen Jörg T
Abstract excerpt
Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined...
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