Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intestinal inflammation observed in IL-2R/IL-2 mutant mice is associated with impaired intestinal T lymphopoiesis.

Gastroenterology - 1 May 2000

Poussier P, Ning T, Chen J, Banerjee D, Julius M

Abstract excerpt

BACKGROUND & AIMS: Although interleukin (IL)-2(-/-) and IL-2Ralpha(-/-) mice develop inflammatory bowel disease, IL-2Rbeta(-/-) animals are apparently free of gut pathology. Intraintestinal T lymphopoiesis is reported to be impaired in IL-2Rbeta(-/-) mice; we have determined whether this characteristic correlated with the apparent resistance of this mutant strain to intestinal inflammation. This led us to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2

Share to Intestinal Mucosa

Share to Mice, Nude

Share to Radiation Chimera

Share to Receptors, Interleukin-2

Share to Thymus Gland

Source

Identifiers

PMID: 10784587
DOI: 10.1016/s0016-5085(00)70174-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intestinal inflammation observed in IL-2R/IL-2 mutant mice is associated with impaired intestinal T lymphopoiesis.PMID 10784587Read ↗

A Unique Subset of Self-specific Intraintestinal T Cells Maintains Gut IntegritySemantic proximity Read ↗

Insights from mouse models of colitis.Semantic proximity Read ↗

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.Semantic proximity Read ↗

Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis.Semantic proximity Read ↗

B cell developmental requirement for the G alpha i2 gene.Semantic proximity Read ↗

Combining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell death.Semantic proximity Read ↗

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant miceSemantic proximity Read ↗

Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in AdulthoodSemantic proximity Read ↗

Interleukin-10-deficient mice develop chronic enterocolitis.Semantic proximity Read ↗

Lessons from genetic models of inflammatory bowel disease.Semantic proximity Read ↗

Development of colonic adenocarcinomas in a mouse model of ulcerative colitis.Semantic proximity Read ↗

Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.