Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Origin, trafficking, and intraepithelial fate of gut-tropic T cells.

The Journal of experimental medicine - 26 Aug 2013

Guy-Grand Delphine, Vassalli Pierre, Eberl Gerard, Pereira Pablo, Burlen-Defranoux Odile, Lemaitre Fabrice, Di Santo James P, Freitas Antonio A, Cumano Ana, Bandeira Antonio

Abstract excerpt

The small intestine epithelium (SI-Ep) harbors millions of unconventional (γδ and CD4(-) CD8(-) NK1.1(-) TCRαβ) and conventional (CD8αβ and CD4) T cells, designated intraepithelial lymphocytes (IELs). Here, we identified the circulating pool of SI-Ep-tropic T cells and studied their capacity to colonize the SI-Ep under steady-state conditions in SPF mice. Developmentally regulated levels of α4β7 endowed recent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Granzymes
Share to Integrins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intestine, Small

Share to Lymphoid Tissue

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Antigen, T-Cell, gamma-delta

Share to Thymocytes

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 23918956
DOI: 10.1084/jem.20122588
PMCID: PMC3754871

Genes

GALT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Origin, trafficking, and intraepithelial fate of gut-tropic T cells.PMID 23918956Read ↗

Intraepithelial Lymphocytes of the IntestineSemantic proximity Read ↗

CD8αα intraepithelial lymphocytes arise from two main thymic precursors.Semantic proximity Read ↗

A dynamic atlas of immunocyte migration from the gutSemantic proximity Read ↗

Resident memory CD8 T cells persist for years in human small intestineSemantic proximity Read ↗

Functional Diversity of Memory CD8 T Cells is Spatiotemporally ImprintedSemantic proximity Read ↗

Nurturing the phenotype: Environmental signals and transcriptional regulation of intestinal γδ T cells.Semantic proximity Read ↗

Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8+ T Cells.Semantic proximity Read ↗

Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes.Semantic proximity Read ↗

Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis.Semantic proximity Read ↗

A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection.Semantic proximity Read ↗

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance.Semantic proximity Read ↗

Innate lymphoid cells: new insights into function and development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.