Article
Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis.
PloS one - 1 Jan 2012
Shalapour Shabnam, Deiser Katrin, Kühl Anja A, Glauben Rainer, Krug Susanne M, Fischer André, Sercan Ozen, Chappaz Stephane, Bereswill Stefan, Heimesaat Markus M, Loddenkemper Christoph, Fromm Michael, Finke Daniela, Hämmerling Günter J, Arnold Bernd, Siegmund Britta, Schüler Thomas
Abstract excerpt
Interleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis. Here we provide evidence that IL-7 also regulates the homeostasis of intestinal epithelial cells (IEC), colon function and the composition of the commensal microflora. In the colon of T cell-deficient, lymphopenic mice,...
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