Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insertion of a telomere repeat sequence into a mammalian gene causes chromosome instability.

Molecular and cellular biology - 1 Jan 2001

Kilburn A E, Shea M J, Sargent R G, Wilson J H

Abstract excerpt

Telomere repeat sequences cap the ends of eucaryotic chromosomes and help stabilize them. At interstitial sites, however, they may destabilize chromosomes, as suggested by cytogenetic studies in mammalian cells that correlate interstitial telomere sequence with sites of spontaneous and radiation-induced chromosome rearrangements. In no instance is the length, purity, or orientation of the telomere repeats at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine Phosphoribosyltransferase
Share to Blotting, Southern
Share to CHO Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Fragility

Share to Gene Targeting

Share to Repetitive Sequences, Nucleic Acid

Share to Telomere

Share to Thymidine Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 11113187
DOI: 10.1128/MCB.21.1.126-135.2001
PMCID: PMC88786

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insertion of a telomere repeat sequence into a mammalian gene causes chromosome instability.PMID 11113187Read ↗

Telomere-related sequences at interstitial sites in the human genomeSemantic proximity Read ↗

Interstitial telomeric sequences promote gross chromosomal rearrangement via multiple mechanismsSemantic proximity Read ↗

Interstitial telomeric sequences promote gross chromosomal rearrangement via multiple mechanisms.Semantic proximity Read ↗

Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric SequencesSemantic proximity Read ↗

DNA sequence analysis of gamma radiation-induced deletions and insertions at the APRT locus of hamster cells.Semantic proximity Read ↗

Heterogeneity in telomere length of human chromosomesSemantic proximity Read ↗

A novel selection system for recombinational and mutational events within an intron of a eucaryotic gene.Semantic proximity Read ↗

Telomere directed fragmentation of mammalian chromosomesSemantic proximity Read ↗

The Role of ATM in Telomere Structure and FunctionSemantic proximity Read ↗

Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline.Semantic proximity Read ↗

Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem CellsSemantic proximity Read ↗

Conserved nucleoprotein structure at the ends of vertebrate and invertebrate chromosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.