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Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences

2 Apr 2018

Abstract excerpt

In many organisms, telomeric sequences can be located internally on the chromosome in addition to their usual positions at the ends of the chromosome. In humans, such interstitial telomeric sequences (ITSs) are nonrandomly associated with translocation breakpoints in tumor cells and with chromosome fragile sites (regions of the chromosome that break in response to perturbed DNA replication). We previously showed...

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PMID: 29610215
DOI: 10.1534/genetics.118.300950

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