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Article

Polymorphism of the beta(2)-adrenergic receptor gene and desensitization in human airway smooth muscle.

American journal of respiratory and critical care medicine - 1 Dec 2000

Moore P E, Laporte J D, Abraham J H, Schwartzman I N, Yandava C N, Silverman E S, Drazen J M, Wand M P, Panettieri R A, Shore S A

Abstract excerpt

We examined the influence of two common polymorphic forms of the beta(2)-adrenergic receptor (beta(2)AR): the Gly16 and Glu27 alleles, on acute and long-term beta(2)AR desensitization in human airway smooth muscle (HASM) cells. In cells from 15 individuals, considered without respect to genotype, pretreatment with Isoproterenol (ISO) at 10(-7) M for 1 h or 24 h caused approximately 25% and 64% decreases in the...

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PMID: 11112125
DOI: 10.1164/ajrccm.162.6.9909046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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