Article
The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization.
The New England journal of medicine - 4 Oct 2001
Dishy V, Sofowora G G, Xie H G, Kim R B, Byrne D W, Stein C M, Wood A J
Abstract excerpt
BACKGROUND: With continuous exposure to beta2-adrenergic agonists, vascular tissue becomes desensitized to agonist-mediated vasodilatation. We studied the effects of two common polymorphisms of the beta2-adrenergic receptor, one at codon 16 and one at codon 27, on agonist-mediated vasodilatation and desensitization in the vascular bed. METHODS: We studied 26 healthy subjects who were selected to represent three...
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