Article
The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo.
Pharmacogenetics - 1 Feb 2003
Bruck Heike, Leineweber Kirsten, Büscher Rainer, Ulrich Anke, Radke Joachim, Insel Paul A, Brodde Otto-Erich
Abstract excerpt
Studies performed have shown that the Arg16Gly allele in beta-adrenoceptors (beta2AR) enhances susceptibility to agonist-induced down-regulation, while the Gln27Glu polymorphism diminishes it. In this study, we tested whether similar phenotypes occur in vivo. We assessed 32 volunteers (mean age 25 +/- 2 years) with different genotypes (group A: wild-type beta2AR, n = 16; group B: homozygous Glu27, n = 10; group...
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