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Article

The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo.

Pharmacogenetics - 1 Feb 2003

Bruck Heike, Leineweber Kirsten, Büscher Rainer, Ulrich Anke, Radke Joachim, Insel Paul A, Brodde Otto-Erich

Abstract excerpt

Studies performed have shown that the Arg16Gly allele in beta-adrenoceptors (beta2AR) enhances susceptibility to agonist-induced down-regulation, while the Gln27Glu polymorphism diminishes it. In this study, we tested whether similar phenotypes occur in vivo. We assessed 32 volunteers (mean age 2...

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Source

Identifiers

PMID: 12563174
DOI: 10.1097/00008571-200302000-00001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12563174-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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