Article
Beta2-adrenoceptor polymorphisms: relation between in vitro and in vivo phenotypes.
Life sciences - 23 Apr 2004
Leineweber Kirsten, Brodde Otto-Erich
Abstract excerpt
Beta2-adrenoceptors are expressed in many cell types throughout the body and play a pivotal role in the regulation of the cardiac, pulmonary, vascular, endocrine and central nervous system. Recent studies have discovered that Beta2-adrenoceptor are polymorphic. Three common polymorphisms appear to influence receptor function: Arg16Gly, Gln27Glu, and Thr164Ile. In vitro studies of agonist-stimulation have shown...
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