Article
Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.
American journal of respiratory cell and molecular biology - 1 Jul 1995
Green S A, Turki J, Bejarano P, Hall I P, Liggett S B
Abstract excerpt
The phenotypic relevance of allelic variation in the structure of the beta 2-adrenergic receptor (beta 2AR) expressed in lung cells is unknown. In particular, altered responsiveness of the beta 2AR expressed on airway smooth muscle, which are responsible for bronchodilation in the treatment of as...
Topics
- Adrenergic beta-2 Receptor Agonists
- Adrenergic beta-2 Receptor Antagonists
- Adrenergic beta-Agonists
- Cells, Cultured
- Cyclic AMP
- Dose-Response Relationship, Drug
- Down-Regulation
- Genotype
- Humans
- Isoproterenol
- Muscle, Smooth
- Pindolol
- Radioligand Assay
- Receptors, Adrenergic, beta-2
- Second Messenger Systems
- Signal Transduction
- Trachea