Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats. [corrected].

Abstract excerpt

Outbred rat strains such as Sprague-Dawley (SD) or Wistar are widely used in epilepsy models, including popular models of temporal lobe epilepsy in which spontaneous recurrent seizures (SRS), hippocampal damage, and behavioral alterations develop after status epilepticus (SE). Such rats are randomly outbred, hence allelic variations can occur across separate colonies, so that outbred rats from different sources...

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