Article
Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Feb 2011
Moody Teena D, Watabe Ayako M, Indersmitten Tim, Komiyama Noboru H, Grant Seth G N, O'Dell Thomas J
Abstract excerpt
Through protein interactions mediated by their cytoplasmic C termini the GluN2A and GluN2B subunits of NMDA receptors (NMDARs) have a key role in the formation of NMDAR signaling complexes at excitatory synapses. Although these signaling complexes are thought to have a crucial role in NMDAR-dependent forms of synaptic plasticity such as long-term potentiation (LTP), the role of the C terminus of GluN2A in...
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