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Article

Pharmacogenetics: a tool for individualizing antineoplastic therapy.

Clinical pharmacokinetics - 1 Nov 2000

Innocenti F, Iyer L, Ratain M J

Abstract excerpt

This article reviews the clinical relevance of pharmacogenetics in cancer chemotherapy, with emphasis on drugs for which genetic differences in enzyme metabolism have been demonstrated to affect patient outcome. About 10% of children with leukaemia are intolerant to mercaptopurine (6-mercaptopurine) because of genetic defects in mercaptopurine inactivation by thiopurine S-methyltransferase. However,...

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Identifiers

PMID: 11108431
DOI: 10.2165/00003088-200039050-00001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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