Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics

Abstract excerpt

A great deal of effort has been spent in defining the pharmacokinetics and pharmacodynamics of investigational and registered anticancer agents. Often, there is a marked variability in drug handling between individual patients, which contributes to variability in the pharmacodynamic effects of a given dose of a drug. A combination of physiological variables, genetic characteristics (pharmacogenetics) and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug Transport and Resistance Mechanisms
• Share to Pharmacogenetics and Drug Metabolism
• Share to Renal Transplantation Outcomes and Treatments