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Article

Genotypes Affecting the Pharmacokinetics of Anticancer Drugs.

Clinical pharmacokinetics - 1 Apr 2017

Bertholee Daphne, Maring Jan Gerard, van Kuilenburg André B P

Abstract excerpt

Cancer treatment is becoming more and more individually based as a result of the large inter-individual differences that exist in treatment outcome and toxicity when patients are treated using population-based drug doses. Polymorphisms in genes encoding drug-metabolizing enzymes and transporters can significantly influence uptake, metabolism, and elimination of anticancer drugs. As a result, the altered...

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Share to Antineoplastic Agents
Share to Cytochrome P-450 Enzyme System
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Glucuronosyltransferase

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 27641154
DOI: 10.1007/s40262-016-0450-z
PMCID: PMC5340837

Genes

DPYD
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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