Article
Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2008
Zhou Cheng-Ji, Molotkov Andrei, Song Lanying, Li Yunhong, Pleasure David E, Pleasure Samuel J, Wang Ya-Zhou
Abstract excerpt
Coloboma, an ocular birth defect seen in humans and other species, is caused by incomplete closure of the optic fissure. Here, we demonstrate that genetic deletion of Lrp6, a bottleneck coreceptor in the canonical Wnt signaling pathway, results in ocular coloboma and neuroretinal patterning defects in mice. The expression of ventral neuroretinal patterning gene Vax2 was conserved but with dorsally shifted...
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