Article
Altered retinoid signaling in the heads of small eye mouse embryos.
Developmental biology - 1 May 2000
Enwright J F, Grainger R M
Abstract excerpt
The vitamin A derivative retinoic acid (RA) is necessary for eye development, though its role in signaling within eye tissues is poorly understood. We investigated this question in two transgenic mouse strains carrying a retinoic acid response element (RARE) fused to beta-galactosidase that identify regions of the embryo expressing activated retinoic acid receptors. Retinoid signaling appears in the retina and...
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