Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases.

doi:10.1002/bies.20009

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Article

Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Apr 2004

Cvekl Ales, Tamm Ernst R

Abstract excerpt

During development of the anterior eye segment, cells that originate from the surface epithelium or the neuroepithelium need to interact with mesenchymal cells, which predominantly originate from the neural crest. Failures of proper interaction result in a complex of developmental disorders such Peters' anomaly, Axenfeld-Rieger's syndrome or aniridia. Here we review the role of transcription factors that have...

Topics

Animals
Anterior Eye Segment
Cell Differentiation
Eye
Eye Diseases
Eye Proteins
Homeodomain Proteins
Humans
Mesoderm
Mice
Models, Biological
Ocular Physiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PAX6 Transcription Factor

Paired Box Transcription Factors

Phenotype

Repressor Proteins

Signal Transduction

Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 15057935
DOI: 10.1002/bies.20009
PMCID: PMC2094210

Genes

PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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