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A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported

4 Jun 2013

Abstract excerpt

Considerable progress has been made in understanding the origins of genomic uracil and its role in genome stability and host defense; however, the main question concerning the basal level of uracil in DNA remains disputed. Results from assays designed to quantify genomic uracil vary by almost three orders of magnitude. To address the issues leading to this inconsistency, we explored possible shortcomings with...

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PMID: 23742752
DOI: 10.1016/j.dnarep.2013.05.002

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