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Article

Administration of 4‑hexylresorcinol increases p53‑mediated transcriptional activity in oral cancer cells with the p53 mutation.

Oncology reports - 1 Sept 2022

Kang Yei-Jin, Yang Won-Geun, Chae Weon-Sik, Kim Dae-Won, Kim Seong-Gon, Rotaru Horatiu

Abstract excerpt

The p53 mutation is inherent in over 50% of human cancers. In head and neck squamous cell carcinoma, the p53 mutation is associated with a poor prognosis. 4‑Hexylresorcinol (4HR) is a pharmacologic chaperone. The present study aimed to investigate the effect of 4HR on p53 transcriptional activity in oral carcinoma cells with p53 mutations. To identify conformational changes induced by 4HR administration, peptides...

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Source

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Identifiers

PMID: 35856441
DOI: 10.3892/or.2022.8375
PMCID: PMC9350967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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