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Article

Biological significance of allele specific loss of the p53 gene in breast carcinomas.

Breast cancer research and treatment - 1 Nov 2009

Wegman Pia P, Marcus Nashwan J, Malakkaran Breezy Paul, Wingren Sten

Abstract excerpt

The p53 tumor suppressor gene has a central role in the defense against cancer, including breast cancer, and contains a polymorphic variant (Arg/Pro) at codon 72 that has been shown to have different biological properties regarding apoptosis and cell cycle arrest. Earlier studies have shown allele specific loss of heterozygosity (LOH) at this particular site and we aimed to investigate its biological relevance in...

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PMID: 18853251
DOI: 10.1007/s10549-008-0212-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Biological significance of allele specific loss of the p53 gene in breast carcinomas.PMID 18853251Read ↗

Study of p53 codon 72 polymorphism in patients with breast cancer.Semantic proximity Read ↗

P53 codon 72 polymorphism in breast cancer.Semantic proximity Read ↗

The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer risk.Semantic proximity Read ↗

Selective loss of codon 72 proline p53 and frequent mutational inactivation of the retained arginine allele in colorectal cancer.Semantic proximity Read ↗

TP53 codon 72 polymorphism and breast cancer in northern Iran.Semantic proximity Read ↗

Polymorphism of TP53 codon 72 showed no association with breast cancer in Iranian women.Semantic proximity Read ↗

Analysis of p53 gene polymorphisms and protein over-expression in patients with breast cancer.Semantic proximity Read ↗

Evidence for an association of TP53 codon 72 polymorphism with breast cancer risk.Semantic proximity Read ↗

LOH rather than genotypes of TP53 codon 72 is associated with disease-free survival in primary breast cancer.Semantic proximity Read ↗

Association of TP53 codon 72 polymorphism with susceptibility to ovarian carcinomas in Serbian women.Semantic proximity Read ↗

Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population.Semantic proximity Read ↗

The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas.Semantic proximity Read ↗

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