Article
Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2000
Kang M J, Park B J, Byun D S, Park J I, Kim H J, Park J H, Chi S G
Abstract excerpt
The p73 gene located at 1p36.3 encodes for a protein with significant similarity to p53. To investigate the penetrance of p73 in gastric carcinogenesis, we analyzed the expression, allelotype, and mutation of p73 in five cell lines and 75 tissues. Although extremely low levels of p73 expression were observed in all noncancerous gastric tissues and four of five cell lines, a significant elevation of p73 was...
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