Article
[Diagnosis of lymph node micrometastases in human lung carcinoma: determination of p53 gene mutations by polymerase chain reaction-temperature gradient gel electrophoresis (PCR-TGGE)].
Ai zheng = Aizheng = Chinese journal of cancer - 1 Jul 2004
Xu Mei-Lin, Wu Bing-Quan, Zhong Hao-Hao, Yang Xia, Heng Wan-Jie
Abstract excerpt
BACKGROUND & OBJECTIVE: Metastasis is one of the most important factors in determining the prognosis of lung cancer patients. However, it is difficult to determine single cancer cell in lymph nodes by routine methods. This study was designed to investigate a sensitive method for detecting lymph node micrometastases in human lung carcinomas. METHODS: Mutation detection for p53 gene (exon 5-8) was performed in 39...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
- Electrophoresis, Agar Gel
- Female
- Genes, p53
- Humans
- Lung Neoplasms
- Lymph Nodes
- Lymphatic Metastasis
- Male
- Middle Aged