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Article

Sequestration of specific tRNA species cognate to the last sense codon of an overproduced gratuitous protein.

Nucleic acids research - 1 Dec 2000

Menez J, Heurgué-Hamard V, Buckingham R H

Abstract excerpt

High-level expression of non-functional model proteins, derived from elongation factor EF-Tu by the deletion of an essential domain, greatly inhibits the growth of Escherichia coli partly deficient in peptidyl-tRNA hydrolase. High-level expression in wild-type cells has little effect on growth. The inhibitory effect is therefore presumably due to the sequestration of essential tRNA species, partly in the form of...

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Share to Carboxylic Ester Hydrolases
Share to Codon
Share to DNA, Recombinant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peptide Chain Elongation, Translational

Share to Peptide Elongation Factor Tu

Share to RNA, Transfer

Share to RNA, Transfer, Amino Acyl

Share to RNA, Transfer, Lys

Source

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Identifiers

PMID: 11095683
DOI: 10.1093/nar/28.23.4725
PMCID: PMC115180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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