Article
Abortive translation caused by peptidyl-tRNA drop-off at NGG codons in the early coding region of mRNA.
The FEBS journal - 1 Oct 2005
Gonzalez de Valdivia Ernesto I, Isaksson Leif A
Abstract excerpt
In Escherichia coli the codons CGG, AGG, UGG or GGG (NGG codons) but not GGN or GNG (where N is non-G) are associated with low expression of a reporter gene, if located at positions +2 to +5. Induction of a lacZ reporter gene with any one of the NGG codons at position +2 to +5 does not influence growth of a normal strain, but growth of a strain with a defective peptidyl-tRNA hydrolase (Pth) enzyme is inhibited....
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