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Article

Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991

Eisenberg S P, Brewer M T, Verderber E, Heimdal P, Brandhuber B J, Thompson R C

Abstract excerpt

Interleukin 1 receptor antagonist (IL-1ra) is a protein that binds to the IL-1 receptor and blocks the binding of both IL-1 alpha and -beta without inducing a signal of its own. Human IL-1ra has some sequence identity to human IL-1 beta, but the evolutionary relationship between these proteins has been unclear. We show that the genes for human, mouse, and rat IL-1ra are similar to the genes for IL-1 alpha and...

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Identifiers

PMID: 1828896
DOI: 10.1073/pnas.88.12.5232
PMCID: PMC51846

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