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Article

Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991

Eisenberg S P, Brewer M T, Verderber E, Heimdal P, Brandhuber B J, Thompson R C

Abstract excerpt

Interleukin 1 receptor antagonist (IL-1ra) is a protein that binds to the IL-1 receptor and blocks the binding of both IL-1 alpha and -beta without inducing a signal of its own. Human IL-1ra has some sequence identity to human IL-1 beta, but the evolutionary relationship between these proteins ha...

Topics

Amino Acid Sequence
Animals
Base Sequence
Humans
Interleukin-1
Introns
Mice
Molecular Sequence Data
Multigene Family
Mutation
Rats
Rats, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Immunologic

Receptors, Interleukin-1

Sequence Alignment

Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 1828896
DOI: 10.1073/pnas.88.12.5232
PMCID: PMC51846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1828896-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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