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Article

Mutator pathways unleashed by epigenetic silencing in human cancer.

Mutagenesis - 1 Jul 2007

Jacinto Filipe V, Esteller Manel

Abstract excerpt

Human cancers exhibit genomic instability and an increased mutation rate due to underlying defects in DNA repair genes. Hypermethylation of CpG islands in gene promoter regions is an important mechanism of gene inactivation in cancer. Many cellular pathways, including DNA repair, are inactivated by this type of epigenetic lesion, resulting in mutator pathways. In this review, we discuss the adverse consequences...

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Share to CpG Islands
Share to DNA Modification Methylases
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exodeoxyribonucleases

Share to Genes, BRCA1

Share to MutL Protein Homolog 1

Share to RecQ Helicases

Share to Werner Syndrome Helicase

Source

Identifiers

PMID: 17412712
DOI: 10.1093/mutage/gem009

Genes

BRCA1
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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