Article

Clonal autoantibodies identify microbial antigen as trigger of autoreactive B cells in systemic sclerosis

2026-03-19

Abstract excerpt

<h4>Objectives</h4> Transformative observations demonstrate unprecedented success of B cell-depleting interventions in many human autoimmune diseases, calling for a deeper understanding of the triggers leading to B cell-mediated autoimmunity and its perpetuation in human disease. Here, we investigated whether the autoreactive B cell response targeting human topoisomerase 1 (TOP1), a hallmark of systemic sclerosis...

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Literature Corpus work: b5c1598b-82b5-5981-a698-075d8be773c8
DOI: 10.64898/2026.03.17.712484

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