Article
CTLA-4 and its role in autoimmune thyroid disease.
Journal of molecular endocrinology - 1 Aug 2003
Chistiakov D A, Turakulov R I
Abstract excerpt
Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of...
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