Article
Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.
Diabetes - 1 Nov 2000
Makimura H, Mizuno T M, Roberts J, Silverstein J, Beasley J, Mobbs C V
Abstract excerpt
In genetically obese leptin-deficient ob/ob mice, adrenalectomy reverses or attenuates the obese phenotype. Relative to lean controls, ob/ob mice also exhibit decreased hypothalamic proopiomelanocortin (POMC) mRNA and increased hypothalamic agouti-related peptide (AGRP) mRNA and neuropeptide Y (NPY) mRNA. It has been hypothesized that this profile of hypothalamic gene expression contributes to the obese phenotype...
Topics
- Adrenalectomy
- Agouti-Related Protein
- Animals
- Blood Glucose
- Blotting, Northern
- Body Weight
- Corticosterone
- Eating
- Gene Expression
- Hypothalamus
- In Situ Hybridization
- Insulin
- Intercellular Signaling Peptides and Proteins
- Leptin