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Article

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

Cell metabolism - 1 Jan 2005

Coppari Roberto, Ichinose Masumi, Lee Charlotte E, Pullen Abigail E, Kenny Christopher D, McGovern Robert A, Tang Vinsee, Liu Shun M, Ludwig Thomas, Chua Streamson C, Lowell Bradford B, Elmquist Joel K

Abstract excerpt

Leptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate nucleus (ARH) has been proposed as an important site of leptin action. To assess the physiological significance of leptin signaling in the ARH, we used mice homozygous for a FLPe-reactivatable, leptin receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16054045
DOI: 10.1016/j.cmet.2004.12.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16054045-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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