Article

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997-11-01

Abstract excerpt

The hormone leptin acts on the brain to regulate feeding, metabolism, and reproduction; however, its cellular targets and molecular mechanisms of action remain to be fully elucidated. The melanocortins, which are derived from the precursor proopiomelanocortin (POMC), are also implicated in the physiological regulation of body weight. POMC-containing neurons express the leptin receptor, and thus it is conceivable t...

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Literature Corpus work: d83b8b1a-1f2a-5910-8e5b-9cdb85beace6
DOI: 10.1210/en.138.11.5063

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