Article
Dehydroepiandrosterone induces a neuroendocrine phenotype in nerve growth factor-stimulated chromaffin pheochromocytoma PC12 cells.
Endocrinology - 1 Jan 2008
Ziegler Christian G, Sicard Flavie, Lattke Peter, Bornstein Stefan R, Ehrhart-Bornstein Monika, Krug Alexander W
Abstract excerpt
The adrenal androgen dehydroepiandrosterone (DHEA) is produced in the inner zone of the adrenal cortex, which is in direct contact to adrenal medullary cells. Due to their close anatomical proximity and tightly intermingled cell borders, a direct interaction of adrenal cortex and medulla has been postulated. In humans congenital adrenal hyperplasia due to 21-hydroxylase deficiency results in androgen excess...
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