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Article

Herpes simplex virus type 1 infection prevents detachment of nerve growth factor-differentiated PC12 cells in culture.

The Journal of general virology - 1 Jul 2002

Moxley Michael J, Block Timothy M, Liu Hsi-Chou, Fraser Nigel W, Perng Guey-Chuen, Wechsler Steven L, Su Ying-Hsiu

Abstract excerpt

In tissue culture, rat pheochromocytoma (PC12) cells differentiated with nerve growth factor (NGF) cease division, extend neuritic processes and acquire many properties characteristic of neuronal cells. In previous work, we have shown that NGF-differentiated PC12 cells can survive infection with herpes simplex virus type 1 (HSV-1) and maintain the viral genome in a quiescent but reactivatable state. In this...

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PMID: 12075077
DOI: 10.1099/0022-1317-83-7-1591

Genes

NGF
LAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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