Article
Differential alterations in antioxidant capacity in cells from Alzheimer patients.
Biochimica et biophysica acta - 15 Nov 2000
Gibson G E, Zhang H, Sheu K R, Park L C
Abstract excerpt
Oxidative stress occurs in brains of Alzheimer's disease (AD) patients. A major question in AD research is whether the oxidative stress is just secondary to neurodegeneration. To test whether oxidative stress is an inherent property of AD tissues, the ability of cultured fibroblasts bearing the AD Presenilin-1 246 Ala-->Glu mutation to handle reactive oxygen species (ROS) was compared to controls. Although ROS in...
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