Article
Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations.
Dementia and geriatric cognitive disorders - 1 Jan 2012
Ringman John M, Fithian Andrew T, Gylys Karen, Cummings Jeffrey L, Coppola Giovanni, Elashoff David, Pratico Domenico, Moskovitz Jackob, Bitan Gal
Abstract excerpt
BACKGROUND: Convergent evidence suggests that oxidative stress plays a central role in the pathology of Alzheimer's disease (AD). We asked if consequently, oxidation of methionine residues to methionine sulfoxide (MetO) was increased in plasma proteins of persons carrying familial AD (FAD) mutations. METHODS: Plasma was collected from 31 persons from families harboring PSEN1 or APP mutations. Using Western blot...
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