Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients.

Journal of cell science - 1 Aug 2002

Uberti Daniela, Carsana Teresina, Bernardi Enza, Rodella Luigi, Grigolato Piergiovanni, Lanni Cristina, Racchi Marco, Govoni Stefano, Memo Maurizio

Abstract excerpt

In this study, we evaluated the response of different human skin fibroblast cultures obtained from eight probable Alzheimer's disease patients and eight non-Alzheimer's disease subjects to an acute oxidative injury elicited by H(2)O(2). This treatment generates reactive oxygen species, which are responsible for DNA damage and apoptosis. To compare the sensitivity of fibroblasts from Alzheimer's disease or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Cyclins

Share to Free Radicals

Share to Hydrogen Peroxide

Share to Oxidative Stress

Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 12118068
DOI: 10.1242/jcs.115.15.3131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients.PMID 12118068Read ↗

Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia SeveritySemantic proximity Read ↗

Familial Alzheimer's Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants.Semantic proximity Read ↗

Alzheimer disease fibroblasts are hypersensitive to the lethal effects of a DNA-damaging chemical.Semantic proximity Read ↗

Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s DiseaseSemantic proximity Read ↗

Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype.Semantic proximity Read ↗

Increased apoptotic cell death in sporadic and genetic Alzheimer's disease.Semantic proximity Read ↗

Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.Semantic proximity Read ↗

Identification of a mutant-like conformation of p53 in fibroblasts from sporadic Alzheimer's disease patients.Semantic proximity Read ↗

Differential alterations in antioxidant capacity in cells from Alzheimer patients.Semantic proximity Read ↗

Death and survival of neuronal cells exposed to Alzheimer's insults.Semantic proximity Read ↗

Mechanisms of Neuronal Death in Alzheimer's DiseaseSemantic proximity Read ↗

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.